• S.M. PANDA



Anthelmintic, , Prosopis africana, Goat, Haemonchus, Phytochemicals


In-vivo anthelmintic and toxicity study of Prosopis africana against Haemonchuscontortusin goats were evaluated for maximum tolerated dose (MTD) and therapeutic dose (TD) in this experiments. Two extracts, aqueous extract of stem bark (AESB) and aqueous extract of leaves (AELF) were obtained. Phytochemical constituents identified in the extracts include Tannins, Flavonoids, Alkaloids, Steroids, Cardiac glycosides and Saponins. In maximum tolerated dose and acute toxicity study, eighteen West African Dwarf goats (aged 5-6 months old) were used. Three dose regimes of 1000 mgkg-1, 2000 mgkg-1and 3000 mgkg-1body weight for each type of extract was orally administered to three goats per dose with each dose being replicated thrice. Animals were observed for 48 hours for apparent signs of toxicity. Four weeks later they were re-examined for signs of delayed cytotoxic effects. At the same time, the goats were evaluated for egg per gram reduction. The results shows at the dose of 1000 mgkg-1, there was no mortality and no evidence of toxicity in both gross and histopathological lesions. At the dose of 2000 mgkg-1to 3000 mgkg-1, various histopathological changes were observed, and at 3000 mgkg-1 stem bark, showed highest reduction (94.2 %) in egg per gram. In this study, 1000 mgkg-1 and 3000 mgkg-1are considered as MTD and TD respectively.


Agbeja, B. O., Adetogun, A. C., Adejoba, O. R. & Osunsina, I. O. (2016). Forestry And Allied Natural ResourceDisciplines in Nigerian Institutions : Inputs For Future Solutions To Dwindling Forest Estate in Nigeria: Proceedings of the 1st Commonwealth Forestry Association ( CFA ) Conference , Nigeria Chapter, Kenya. Nairobi.

Al-Shaibani, I. R. M., Phulan, M. S. & Sheikh, M. (2009).Anthelmintic Activity of Fumariaparviflora (Fumariaceae) against Gastrointestinal Nematodes of sheep.InternationalJournal of Agriculture and Biology 11.431-436.

Burkill, H.M. (1985). The useful plants to West tropical Africa, vol. 3. 123 – 127

Choji, T. P. P. Ngokere, A. A., Ogenyi, S. I., Kumbish, P. R. (2015). Histo Architectural Evaluation of Conventional Versus Two Rapid Microwave Processing Technique. British Biotechnology Journal 8(3)1-9

Coles, G. C., Bauer, C., Borgsteede, F. H., Geerts, S., Klei, T. R., Taylor, M. A.(1992).World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.)

Dalziel, J. M. (1955). The Useful Plants of West Tropical Africa. Crown Agents for Overseas Government and Administration London.

Dogar, Z. M., Aslam, F., Aslam, M. A., Tabassum, S., Rauf, A., Ahmed, K. (2012). In vivo and In vitro Antihelmintic Activity of Gemmotherapeutically Treated Azadirachta indica ( neem ) against Gastrointestinal Nematodes of sheep and Earthworms. African Journal of Pharmacy and Pharmacology6. (46), 3171–3179.

Duncan, D.B. (1955). Multiple Ranges and Multiple F-Test Biometrics, 11:1-42.

Elelu, N., Ambali, A., Coles, G. C. & Eisler, M. C. (2016). Cross-Sectional Study of Fasciola gigantica and other Trematode Infections of Cattle in Edu Local Government Area , Kwara State. Parasites & Vectors5. 1–11.

Ezeke, A.C., Akah, P.A., Okoli, C.O., Udegbunam, S., Okwume, N., Okeke, C. (2010). Medicinal Plants Used in Wound Care: A Study of Prosopis africana (Fabaceae) Stem Bark. Indian Journal of Pharmaceutical Sciences72. (6), 334–339.

Kolapo, A.L., Okunade, M.B., Adejumobi, J.A. & Ogundiya, M.O. (2009). Phytochemical Composition and Antimicrobial Activity of Prosopis africana Against Some Selected Oral Pathogens. World Journal of Agricultural Sciences 5. (1), 90–93.

Lorke, D. (1983). A New Approach to Practical Acute Toxicity Testing.Archives of Toxicology. 54, 275-287.

Maria Lenira Leite-Browning. (2017). Haemonchus contortus ( Barber Pole Worm ) Infestation in Goats.

NIMET, (2019). Nigerian Meteorological Agency, Lafia Service Station, Nasarawa State, Nigeria.

SAS Institute. (2002). SAS System for mixed Models. SAS Institute Carry, NC.

Suleiman, M. M., Mamman, M., Aliu, Y. O. & Ajanusi, J. O. (2014). Anthelmintic Activity of theCrude Methanol Extract of Xylopia aethiopica against Nippostrongylus brasiliensis in rats.Veterinarski Arhie75. (6), 487–495

Williams, C. E. (2009). Trease and Evans Pharmacognosy. In C. E. Williams (Ed.), 16thEdition. Bailliere Tindall, London. (16th ed., p. 614). london: First edition. BailliereTindall, London.